Yes, any card can be played as a regular or special. The only exception is that ace, queen, king, and jack cannot be used as a special because they have no affect. The ten cannot be played as a regular because it also has no affect. It is up to the player playing the card to decide how a card is played. You can decide to draw a card or play one during your turn. The only except are twos, which can be played during your opponent's turn if used as a regular card. This does not affect your next turn. If you run out of cards you must draw a new one instead of playing one. If you run out of cards you must reshuffle the discarded cards and reuse them as a new deck. Unless you want to play with a joker the game does not end until somebody forfeits.

There are also cards that can be put into play such as eights, queen, and kings when played as regulars. These cards stay active and their affects stay active until the opponent does something to remove them such as playing a two, six, nine, or jack as a regular. A card that is used but is not put in play is immediately discarded.